منابع مشابه
Thalassemia: cardiac iron and chelators.
1. Díez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003;148:293-300. 2. Leth H, Andersen KK, Frystyk J, Tarnow L, Rossing P, Paeving HH, et al. Elevated levels of high-molecularweight adiponectin in type 1 diabetes. J Clin Endocrinol Metab. 2008;93:3186-91. 3. Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and disease. Dia...
متن کاملRisks of copper and iron toxicity during aging in humans.
Copper and iron are essential but also toxic metals. Their essentiality is known, but their toxicity, except for the genetic overload diseases, Wilson's disease and hemochromatosis, is not so well known. Yet, their toxicities are so general in the population that they are a looming public health problem in diseases of aging and in the aging process itself. Both metals are transition elements, a...
متن کاملRelative Oral Efficacy and Acute Toxicity of Hydroxypyridin-4-One Iron Chelators in Mice
The relationship between the oral efficacy and the acute toxicity of hydroxypyridin4one iron chelators has been investigated to clarify structure-function relationships of these compounds in vivo and to identify compounds with the maximum therapeutic safety margin. By comparing “Fe excretion following oral or intraperitoneal administration of increasing doses of each chelator to iron-overloaded...
متن کاملRelative oral efficacy and acute toxicity of hydroxypyridin-4-one iron chelators in mice.
The relationship between the oral efficacy and the acute toxicity of hydroxypyridin-4-one iron chelators has been investigated to clarify structure-function relationships of these compounds in vivo and to identify compounds with the maximum therapeutic safety margin. By comparing 59Fe excretion following oral or intraperitoneal administration of increasing doses of each chelator to iron-overloa...
متن کاملEffects of iron, copper, cobalt, and their chelators on the cytotoxicity of bleomycin.
Bleomycin is widely used for treating several types of human tumors as well as a variety of experimental tumors. The ability of this antibiotic to bind and to damage DNA has been proposed to be responsible for its antitumor effect. Bleomycin is also a good chelator for several metals, e.g., iron, copper, and others. Bleomycin:metal complexes have been investigated in detail particularly for the...
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ژورنال
عنوان ژورنال: Current Pharmacology Reports
سال: 2016
ISSN: 2198-641X
DOI: 10.1007/s40495-016-0068-8